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What is NFAT?

Its transcription factors, nuclear factor of activated T-cells (NFAT), play a critical role in triggering immunity. Most immune cells express at least one member of the NFAT family. In addition to developing cardiac, skeletal muscle, and neurologic tissues, NFAT promotes.

How does calcineurin activate NFAT?

Ca2+ influx increases when SLE T cells are activated through their TCR, which promotes NFAT translocation to the nucleus, and thus transcriptional activation of CD40 ligand, which ncreases, which induces calcineurin-mediated NFAT translocation to the nuclei, and then promotes transcriptional upregulation of CD40 ligand, a co-stimulatory molecule that induces antibody production and dendritic cell activation (99).

What is NFAT in T cells?

Additionally, the importance of NFAT proteins to the immune system has come to light. It is important to understand that NFAT proteins regulate more than just activation in T cells. They play a role in thymocyte development, T-cell differentiation, and self-tolerance as well.

What activates NFAT?

It binds to calcium ions and functions as a transcription factor in activated T cells. locked away in the cell cytoplasm where it is inactive. When T-cells are activated, calcium influx activates the phosphatase calcineurin, which then dephosphorylates NFAT, making it active.

What genes does NFAT regulate?

It was initially identified in T cells, but now comprises five genes that control the immune system, angiogenesis, cardiac valve development, myocardial development, axonal guidance, bone homeostasis, and development of cancer.

What does NFAT do immune system?

In order for NFAT proteins to be translocated to the nucleus and for gene transcription to occur, they must be dephosphorylated by activated calcineurin. As T cells become activated, calcium–calcineurin–NFAT is activated by engagement of their receptors (TCR).

What is NFAT activated by?

NFAT is activated and translocated to the nucleus after dephosphorylation by caldineurin. The anti-inflammatory drugs cyclosporin A (CsA) and FK506, which bind to the intracellular immunophilin receptors cyclophilin and FKBP12, respectively, inhibit the catabolization of calcineurin.

Does calcineurin phosphorylate NFAT?

In addition to its role in catalysis, caldineurin has diverse functions in the body. Apoptosis, cell cycle regulation, muscle and heart function, transcription regulation, learning and memory, and T-cell activation are some of its many physiological functions.

What is the role of calcineurin?

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